Function over score.

Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.

Same here.

You have two changes at once here. You cannot attribute anything until one of them moves.

Worth asking what specifically was measured. Pain scores move with mood and function does not.

A plausible mechanism is not an outcome, and this class is the textbook example.

Where does the human data stop and the extrapolation begin? That is the whole thread.