Where does the human data stop and the extrapolation begin? That is the whole thread.

Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.

A plausible mechanism is not an outcome, and this class is the textbook example.

Worth asking what specifically was measured. Pain scores move with mood and function does not. Three weeks in on a long-term dependence and it lines u…

A certificate of analysis answers one question and gets quoted as though it answers four.

Imprint first, country second, colour last. And photograph both sides in daylight.