Worth asking what specifically was measured. Pain scores move with mood and function does not.

You have two changes at once here. You cannot attribute anything until one of them moves.

Where does the human data stop and the extrapolation begin? That is the whole thread.

Reference ranges differ between labs, so comparing two reports is close to meaningless.

Loose evidence and no evidence are different, and people overcorrect in both directions.

Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.