How long before you can reasonably say something is or is not doing anything?

Sorry, probably obvious, but where do you even start with something blank?

Do you contact the customs office or the carrier first? Not on a controlled medicine on a flight but the pattern is familiar.

Following this because I am in the same place and have no idea what to ask at the appointment.

My pharmacist has become my actual doctor and I am at peace with it.

Is it normal to feel worse before better? Nobody told me that.