What is the first thing you would read if you were starting from zero?

Access to mugs should be on the clinical questionnaire.

Where does the human data stop and the extrapolation begin? That is the whole thread.

Same here.

Same here.

Worth repeating that this is not medical advice and the answer often depends on who you are.

File early. Currently on Serbia myself.

How long before you can reasonably say something is or is not doing anything?

You are not imagining it and you are not being difficult. Document it and take the document in.