Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.

Ten percent cuts, of the current dose not the original. That is the arithmetic that keeps it survivable.

Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.

Reference ranges differ between labs, so comparing two reports is close to meaningless.

You have two changes at once here. You cannot attribute anything until one of them moves.

Worth asking what specifically was measured. Pain scores move with mood and function does not.

You have two changes at once here. You cannot attribute anything until one of them moves.

Where does the human data stop and the extrapolation begin? That is the whole thread.

You have two changes at once here. You cannot attribute anything until one of them moves.