Trying to separate three different claims about modafinil: that it is the right molecule, that it is the right dose, and that it does something useful.
Mechanism is not outcome, and a plausible pathway is the most expensive kind of evidence there is.
I would rather have a narrow conclusion and be right than a broad one and be interesting.
My rule now: if a claim cannot survive being written down with the numbers attached, it is marketing.
Where does the human data stop and the extrapolation start?
Is a baseline blood test really necessary before starting something like this?
Same here.
If it needs three other compounds to notice, you have not tested the first one.
Nobody has ever been talked out of a stack by a stranger on the internet.
How long before you can reasonably say something is or is not doing anything?