Sulbutiamine at what most people describe as a standard dose gave me nausea on an empty stomach for the first 8 days.
Mechanism is not outcome, and a plausible pathway is the most expensive kind of evidence there is.
Sample size, blinding, and who paid for it. Those three questions kill most of the confidence in most of these threads.
Fortified food counts toward the total and is always forgotten.
The interesting question is not whether it works but for whom and at what cost.
What is the first thing you would read if you were starting from zero?
An inconclusive account is useful if it stops the next person mistaking a story for a controlled comparison. Not on sulbutiamine but the pattern is familiar.
Underdosing and tolerance are indistinguishable from the inside, and everyone picks the flattering explanation.
Same here.
Nausea on an empty stomach was my main issue with sulbutiamine too.
Baseline first.
Most of the popular protocol is borrowed from a clinical population and applied to healthy people without comment.
Same here.
Loose evidence is not nothing, but a washout either side is the only reason to trust your own take. Nausea on an empty stomach was my main issue with sulbutiamine too.
Stupid question: how do you know whether what is in the vial matches the label at all?
Same here.
This is the kind of post the forum exists for.
Most of the popular protocol is borrowed from a clinical population and applied to healthy people without comment.
Sleep, food, or the compound? Yes.
A plausible mechanism is not an outcome, and this class is the textbook example. Nausea on an empty stomach was my main issue with sulbutiamine too.