Worth repeating that this is not medical advice and the answer often depends on who you are. Currently on a wrong entry in the record myself.

Domain age is one of the few signals that is expensive to fake and free to check.

Domain age is one of the few signals that is expensive to fake and free to check. Same for me with the non-prescription boundary, unfortunately.

Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.

Where does the human data stop and the extrapolation begin? That is the whole thread.

You have two changes at once here. You cannot attribute anything until one of them moves.