If it needs three other compounds to notice, you have not tested the first one.

Three questions kill most of the confidence in a thread like this: sample size, blinding, who paid.

Changing prescriber does not reset anything, and people discover that the hard way.

You are not imagining it and you are not being difficult. Document it and take the document in.

I would stop trying to convey how bad it is and start saying what you want them to do.