Read methods.

Worth asking what specifically was measured. Pain scores move with mood and function does not.

Where does the human data stop and the extrapolation begin? That is the whole thread.

Reference ranges differ between labs, so comparing two reports is close to meaningless. How long have you been on a long-running thread?

Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.

You have two changes at once here. You cannot attribute anything until one of them moves. Tolerance was my main issue with a book about a drug too.

Where does the human data stop and the extrapolation begin? That is the whole thread.