Reference ranges differ between labs, so comparing two reports is close to meaningless.

Function over score.

You have two changes at once here. You cannot attribute anything until one of them moves.

Worth asking what specifically was measured. Pain scores move with mood and function does not.

Domain age is one of the few signals that is expensive to fake and free to check.

Reference ranges differ between labs, so comparing two reports is close to meaningless.

Where does the human data stop and the extrapolation begin? That is the whole thread.

Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.

You have two changes at once here. You cannot attribute anything until one of them moves.