How long before you can reasonably say something is or is not doing anything?

How do you tell the difference between the drug working and just a good week?

Enteric coatings should not be crushed. The pellets are the delivery mechanism.

Did not know half of this. Thanks.

Following this because I am in the same place and have no idea what to ask at the appointment.

Is it normal to feel worse before better? Nobody told me that.