Worth asking what specifically was measured. Pain scores move with mood and function does not. Not on a practice change but the pattern is familiar.

Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.

You have two changes at once here. You cannot attribute anything until one of them moves.

Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.

“Registered with” is doing an enormous amount of work in that sentence.

Imprint databases are mostly US-centric. A confident hit for another market is still a guess.