Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.

Ten percent cuts, of the current dose not the original. That is the arithmetic that keeps it survivable.

Interdose restlessness is distinct from the original symptom and worth naming separately.

How long before you can reasonably say something is or is not doing anything? Tolerance was my main issue with memantine too.

Baseline first. Without a baseline the after picture is decoration.

Interdose restlessness is distinct from the original symptom and worth naming separately.

Three month limits are cumulative across parcels in more places than people realise.