Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers. A year in on melatonin and it l…

Same shape here, different drug. The thing that helped was documenting the refusal rather than re-arguing it. They refer rather than write.

Loose evidence and no evidence are different, and people overcorrect in both directions.

Where does the human data stop and the extrapolation begin? That is the whole thread. Same for me with semaglutide, unfortunately.

Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.

Same here.