Loose evidence and no evidence are different, and people overcorrect in both directions.

Stupid question: how do you know whether what is in the vial matches the label at all?

Where does the human data stop and the extrapolation begin? That is the whole thread.

Is a baseline blood test really necessary before starting something like this?

Worth asking what specifically was measured. Pain scores move with mood and function does not.

A plausible mechanism is not an outcome, and this class is the textbook example.