Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers.

Half of what people describe as tolerance is a change in the underlying condition, and the two need different answers. A fortnight in on trimethoprim …

You have two changes at once here. You cannot attribute anything until one of them moves.

You have two changes at once here. You cannot attribute anything until one of them moves.

Same.

Worth asking what specifically was measured. Pain scores move with mood and function does not.

Test one thing at a time. It feels slower and it is the only way to learn anything.