Trying to separate three different claims about berberine: that it is the right molecule, that it is the right dose, and that it does something useful. The comparison group matters more than the compound when the outcome is something as fuzzy as focus.
Read methods.
A plausible mechanism is not an outcome, and this class is the textbook example.
An inconclusive account is useful if it stops the next person mistaking a story for a controlled comparison.
What is the first thing you would read if you were starting from zero? Mild sedation was my main issue with berberine too.
Is a baseline blood test really necessary before starting something like this?
How long before you can reasonably say something is or is not doing anything?
Read methods. Two years in on berberine and it lines up.
Sleep, food, or the compound? Yes.
An inconclusive account is useful if it stops the next person mistaking a story for a controlled comparison.
What is the first thing you would read if you were starting from zero?
Read methods. Same for me with berberine, unfortunately.
Most of the popular protocol is borrowed from a clinical population and applied to healthy people without comment. Currently on berberine myself.
Cold storage, light protection, date on the vial. Boring, removes half the variables.
A plausible mechanism is not an outcome, and this class is the textbook example.