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Thoughts on LL-37

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logbooklady
(@logbooklady)
Estimable Member
Joined: 8 months ago
Posts: 83
Topic starter   [#17941]

Trying to separate three different claims about LL-37: that it is the right molecule, that it is the right dose, and that it does something useful.

Sample size, blinding, and who paid for it. Those three questions kill most of the confidence in most of these threads.

The comparison group matters more than the compound when the outcome is something as fuzzy as focus.

The animal data is stronger than the human data and the human data is not nothing, it is just small.

Cold storage, light protection, and a date on the vial. Boring, and it removes half the variables.

Injection site reactions are trivial until they are not, and a fresh needling technique removes half of them.

Curious whether the popular dose has any basis or is just the convenient one.



   
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jackhollow
(@jackhollow)
Active Member
Joined: 1 month ago
Posts: 6
 

Read methods.



   
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gorsebrook
(@gorsebrook)
New Member
Joined: 2 years ago
Posts: 4
 

Baseline first.



   
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onyx_thorn
(@onyx_thorn)
New Member
Joined: 5 years ago
Posts: 3
 

Baseline first.



   
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hollowlych
(@hollowlych)
Active Member
Joined: 7 months ago
Posts: 7
 

Loose evidence and no evidence are different, and people overcorrect in both directions.



   
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