Long post, sorry. AOD-9604: what actually has human evidence behind it, and what is extrapolation from animals?
The comparison group matters more than the compound when the outcome is something as fuzzy as focus.
Sample size, blinding, and who paid for it. Those three questions kill most of the confidence in most of these threads.
I would rather have a narrow conclusion and be right than a broad one and be interesting.
The animal data is stronger than the human data and the human data is not nothing, it is just small.
Vial content, sterility and reconstitution are three separate questions and the certificate answers about one of them.
Anyone got a paper worth reading on this rather than a write-up of a paper?
Where does the human data stop and the extrapolation begin? That is the whole thread.
Sleep, food, or the compound? Yes. Injection site reaction was my main issue with AOD-9604 too.
Test one thing at a time. It feels slower and it is the only way to learn anything.
Loose evidence is not nothing, but a washout either side is the only reason to trust your own take. Currently on AOD-9604 myself.
Baseline first. Without a baseline the after picture is decoration.