Long post, sorry. AOD-9604: what actually has human evidence behind it, and what is extrapolation from animals?
Sample size, blinding, and who paid for it. Those three questions kill most of the confidence in most of these threads.
Mechanism is not outcome, and a plausible pathway is the most expensive kind of evidence there is.
What would change your mind about this?
Sleep, food, or the compound? Yes. Not on AOD-9604 but the pattern is familiar.
Narrow conclusion, briefly right. Broad conclusion, interestingly wrong. I know which I keep choosing.
Baseline first. Same for me with AOD-9604, unfortunately.
Three questions kill most of the confidence in a thread like this: sample size, blinding, who paid.
Baseline first. Same for me with AOD-9604, unfortunately.
An inconclusive account is useful if it stops the next person mistaking a story for a controlled comparison.
Is a baseline blood test really necessary before starting something like this?