I have been running nicotine for a year and the honest summary is that the effect is smaller than the internet suggests and real.
The effect size I actually noticed is roughly a third of what the write-ups imply, and it took a year to be sure.
If you need three other compounds to notice the first one, you have not tested the first one.
What is the strongest human evidence anyone here has actually read, not skimmed?
Narrow conclusion, briefly right. Broad conclusion, interestingly wrong. I know which I keep choosing.
An inconclusive account is useful if it stops the next person mistaking a story for a controlled comparison.
This board overrates bloodwork. A number moving is not the outcome you wanted. A year in on nicotine and it lines up.
Narrow conclusion, briefly right. Broad conclusion, interestingly wrong. I know which I keep choosing. Not on nicotine but the pattern is familiar.