Long post, sorry. Nuvigil (armodafinil): what actually has human evidence behind it, and what is extrapolation from animals?
Mechanism is not outcome, and a plausible pathway is the most expensive kind of evidence there is.
My rule now: if a claim cannot survive being written down with the numbers attached, it is marketing.
I would rather have a narrow conclusion and be right than a broad one and be interesting.
Sleep is the limiting factor and it compounds quietly for a fortnight before it is obvious.
What is the strongest human evidence anyone here has actually read, not skimmed?
Most of the popular protocol is borrowed from a clinical population and applied to healthy people without comment.
Read methods.
Baseline first. Without a baseline the after picture is decoration.
Where does the human data stop and the extrapolation begin? That is the whole thread.
An inconclusive account is useful if it stops the next person mistaking a story for a controlled comparison.
What is the first thing you would read if you were starting from zero?
Loose evidence is not nothing, but a washout either side is the only reason to trust your own take.
This board overrates bloodwork. A number moving is not the outcome you wanted.
Baseline first.
I would take the narrow conclusion. Broad ones are more interesting and less true.