Long post, sorry. Provigil (modafinil): what actually has human evidence behind it, and what is extrapolation from animals?
What the stimulant class does pharmacologically does not require the subjective effect to be large to be real.
I have started logging dose, time, and sleep because otherwise the anecdote is just a mood.
Baseline first. Without a baseline the after picture is decoration.
Mechanism is not outcome, and a plausible pathway is the most expensive kind of evidence there is.
Appetite suppression makes the sleep problem worse, which is the actual trap.
Happy to be corrected on any of the above.
Most of what is called evidence here is one person, one vial, one month.
Most of the popular protocol is borrowed from a clinical population and applied to healthy people without comment.
What is the first thing you would read if you were starting from zero?
Is a baseline blood test really necessary before starting something like this?
Narrow conclusion.
What is the first thing you would read if you were starting from zero?
Where does the human data stop and the extrapolation begin? That is the whole thread.
Same here.