I have been on nirmatrelvir-ritonavir for two months and the thing nobody warned me about is the side effects.

Some days are fine and some are not and there is no pattern I can find, which makes it hard to plan anything.

The generic switch was the only change and it was noticeable for about three weeks.

Cold and heat sensitivity turned out to be part of it and is barely mentioned anywhere.

There is a point in the afternoon where the effect is gone and the restlessness starts, and that point has moved earlier over two months.

Rebound after the course is documented and should not be a surprise.

Not looking for a protocol, just perspective.