Reconstitution arithmetic is only half the problem. The other half is what was in the vial.

Underdosing and tolerance are indistinguishable from the inside, and everyone picks the flattering explanation.

Narrow conclusion, briefly right. Broad conclusion, interestingly wrong. I know which I keep choosing.

Nobody has ever been talked out of a stack by a stranger on the internet.

Baseline first.

Same here.

Currently on tamoxifen myself.

Underdosing and tolerance are indistinguishable from the inside, and everyone picks the flattering explanation. Currently on tamoxifen myself.

Same here.

Narrow conclusion, briefly right. Broad conclusion, interestingly wrong. I know which I keep choosing.

Is a baseline blood test really necessary before starting something like this?

Read the methods section. It is the only part that says whether the conclusion is allowed to exist.

Test one thing at a time. It feels slower and it is the only way to learn anything.

Log dose, time and sleep. Ten seconds a day and it turns the anecdote into something you can look at.

A plausible mechanism is not an outcome, and this class is the textbook example.

Reconstitution arithmetic is only half the problem. The other half is what was in the vial. How long have you been on tamoxifen?