Long post, sorry. KPV: what actually has human evidence behind it, and what is extrapolation from animals?
Narrow conclusion.
Most of what is called evidence here is one person, one vial, one month.
Same here.
Same here.
A plausible mechanism is not an outcome, and this class is the textbook example. Same for me with KPV, unfortunately.
Is a baseline blood test really necessary before starting something like this?
How long before you can reasonably say something is or is not doing anything? Currently on KPV myself.
Loose evidence and no evidence are different, and people overcorrect in both directions. A fortnight in on KPV and it lines up.
Same here.
What is the first thing you would read if you were starting from zero?
Read the methods section. It is the only part that says whether the conclusion is allowed to exist.
What is the first thing you would read if you were starting from zero?
A plausible mechanism is not an outcome, and this class is the textbook example.
Baseline first.